Effect of Caffeic Acid Phenethyl Ester on Gingival Tissue Inflammation in Experimental Periodontitis: Experimental Study

Objective: This study aimed to investigate the anti-inflammatory effect of two different dosages caffeic acid phenethyl ester (CAPE) on lipopolysaccharide-induced experimental periodontitis (EP). Material and Methods: Forty Sprague Dawley rats were randomly divided into four groups: control, EP, EP treated with 5 μmol/kg/day CAPE (EP+CAPE 5), 10 10). Followed by was administered intraperitoneally EP+CAPE groups for 28 days. Samples investigated biochemically using an enzyme-linked immunosorbent assay kit alveolar bone loss measured morphometrically. Results: In both groups, levels interleukin-1 beta tumor necrosis factor alpha (TNF-α) in gingiva significantly lower than those group (p<0.001). The decrease tissue TNF-α greater a dose-dependent manner. Serum analysis cytokines showed no significant difference between groups. Conclusion: Within limits this study, is claimed be novel agent improving results periodontal therapy. may valuable as alternative host modulating treatment disease.